Located in the center of New York State, Onondaga County is home to the City of Syracuse. We are within 350 of all major cities in the northeast, conveniently situated at the intersection of Interstate 81 and the NYS Thruway. Local Amtrak and Greyhound terminals are located at our Regional Transportation Center. Arriving by air brings you into our modern Hancock International Airport, while the NYS Barge Canal System provides local connection by boat to the Great Lakes and the St. Lawrence Seaway.